To achieve this overall aim, the project focuses on 4 interrelated work packages.
WP1 - Pre-analytical work and clinical studies including microdialysis
The overall objective of WP1 is effectively run the clinical trial and deliver tissue penetration dataWP2 - Bioanalysis of gepotidacin levels
The overall objective of WP2 is measure gepotidacin levels in samples obtained from WP1.
WP3 – Translational studies and data analysis
The overall objective of WP3 is to build PKPD, PBPK and PopPK models to predict tonsil and prostate distribution of gepotidacin .